Bremelanotide (Sexual Health)
Bremelanotide is a peptide used as a treatment for sexual dysfunction in both men and women. In men, it can induce erections and restore erectile function. In women, it can influence subjective arousal and desire.
- Benefits: Effective Alternative to Other Therapies
Bremelanotide provides a treatment alternative for individuals who can’t tolerate other treatments well or for men who do not respond to other treatments, such as sildenafil and tadalafil, which can lose their effectiveness over time.
- Not Dependent on Sexual Stimulation: Many treatment options, such as sildenafil and tadalafil, require sexual stimulation to be effective, which can cause confidence issues. Bremelanotide will initiate an erection without the need for sexual stimulation.
- Effective Alternative for Psychological Ed: Research has shown that synthetic metabotropic peptides can initiate erections in men with psychogenic erectile dysfunction (erectile dysfunction caused by predominantly psychological versus physiologic causes).
- About Bremelanotide: Bremelanotide, also known as PT-141, is a newer class of drugs called melanocortins, which act on the brain neurotransmitter dopamine to increase sexual desire. Bremelanotide activates the hypothalamic and limbic emotional structures in the brain, which naturally flare during sexual arousal.
Specifically, Bremelanotide acts on the preoptic nucleus, which is essential for blood flow to the penis and vulva. The mechanism of action of Bremelanotide involves activating the brain pathways that drive the body’s normal sexual responses. Bremelanotide has been studied in more than 30 clinical trials involving over 2,500 participants, with positive outcomes in both men and women.
Side Effects: Most often, there is a flushing sensation and temporary abdominal cramping, both of which dissipate within several minutes. The libido increases two to six hours after injections, with a peak at around 12 hours, and can last for 24 to 36 hours. Combining this with a PDE-5 medication (Viagra, Cialis) may be a successful combination, but should only be done when your medical provider is aware of your condition and medication use. There is a risk for priapism (prolonged erection) with the use of this injection with or without other medications.
BPC 157 (Immune System Support)
BPC 157 can be prescribed to help repair inflammation-related damage, promote gut healing, accelerate wound healing, strengthen and heal tendons, ligaments, and bones, and reduce pain from muscle sprains, tears, and other tissse damage, such as skin burns.
- Benefits: Improves Joint Health
BPC 157 promotes healthy tendon and ligament healing by accelerating the growth and spread of fibroblasts, which are cells found in connective tissues that are involved in the creation of collagen.
BPC 157 has muscle- and tendon-healing properties, which can help repair sports-related injuries and injuries sustained during gym workouts
With its well-known fracture- and wound-healing properties, BPC 157 injection therapy promotes bone repair and improves overall bone health.
- Protects Against Intestinal & Gut Damage
BPC 157 can help address issues related to short gut (short bowel syndrome, or SBS) and cepair damaged tissues caused by inflammatory bowel disease (IBD). It can also act as an anti-ulcer peptidergic agent and an NSAID (nonsteroidal anti-inflammatory drug. NSAIDs can be toxic to the gut, and frequent use can lead to ulcers and irritation of the bowels. BPC 157 can counteract the symptoms associated with aspirin use, such as bleeding.
- About BPC 157: BPC is a peptide composed of 15 15-chain sequences of amino acids. It is a partial sequence of body-protecting compounds discovered in isolation from human gastric juice. BPC works by accelerating the rate of angiogenic repair. Angiogenesis is a key dynamic process in wound healing that enables the formation of new blood vessels from preexisting ones and contributes to the organization of the microvascular network. It is also strongly associated with the protection of the gastric tract.
For optimal results, BPC 157 is most likely therapeutically effective when injected intramuscularly (IM) or subcutaneously (SC). Most synthetic peptides are poorly absorbed when taken orally. However, if gut repair is the focus, this is recommended as an oral supplement.
- Instructions: Once reconstituted, it must be stored in the refrigerator. Instructions are included with each kit.
Clinical Research: The Promoting effect of Pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. It dissolves readily in water and requires no carrier for application. In experimental studies, it has been shown to enhance healing of various wounds, including gastric ulcers, skin, cornea, muscle, colon-colon anastomosis, colo-rectal fistula, and segmental bone defects. It was also found to accelerate the healing of the transected rat Achilles tendon and medial collateral ligament of the knee. It is currently in clinical trials for the treatment of inflammatory bowel disease.
Cerebrolysin
Cerebrolysin (synonym FPE 1070) is a nootropic drug that consists of low-molecular peptides that possess neuroprotective and neurotrophic repair properties. The active fragment of Cerebrolysin consists of proteins with very low molecular masses,n ot exceeding 10,000 daltons. This means they can penetrate the blood-brain (or blood-SCF) barrier and reach neurons directly, enabling the drug to exhibit organ-specific combined effects in the brain. Cerebrolysin has been shown to have neurotrophic effects similar to those of nerve growth factors, thereby stimulating peripheral and central neurons. It enhances the efficiency of the brain’s aerobic metabolic processes and intracellular peptide synthesis. The neuroprotective properties of this nootropic agent help protect neurons from lactocidosis by preventing the formation of free radicals and have been studied in Parkinson’s disease, Alzheimer’s disease, MS, ALS, TBI, and stroke.
- Clinical Research: Cerebrolysin (Cere) is a neurotrophic compound. It has been shown to be effective in the treatment of Alzheimer’s disease (AD) in earlier trials. In this multicenter, randomized, double-blind, placebo-controlled, parallel-group study, patients were injected intravenously with either a placebo or 30mL of Cof, five days per week for four weeks.
Effects on cognition and global function were evaluated with the Alzheimer’s Disease Assessment Scale – Cognitive Subscale (ADAS-Cog) and the Clinician Interview-Based Impression of Change with Caregiver Input scale (CIBIC+) at 4, 12, and 24 weeks after the start of injections. 1A total of 92 patients were enrolled;95 were randomized to placebo, a nd 97 to Cere. At baseline, there was a significant difference between groups for age, age of onset of dementia, and the number of patients with hallucinations.
At week 12, there was a significant difference in the CIBIC + (p=0.033) in favor of Cere. The number of CIBIC+ responders (score < 4) was significantly higher (p=0.007), with 68 (76%) in the Cere group and 51 (57%) in the placebo group. Trends were noted in the Disability Assessment in Dementia scale and the Cornell Depression Scale. Adverse events were recorded in 73% of placebo and 64% of Cere patients. The most common adverse events were headaches, dizziness, weight loss, and anxiety.
Conclusions: Cere treatment was well tolerated and resulted in significant improvements in the global score two months after the end of active treatment.
Dihexa
Dihexa is a peptide variant of angiotensin IV that has been shown to significantly improve cognitive function in animal models of diseases such as Alzheimer’s. Disease: Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance learning and memory acquisition, consolidation, and recall in animal models when administered centrally or peripherally. In a neurotrophic activity assay, Dihexa was found to be 7 orders of magnitude more potent than BDNF. It may help repair the brain and nerves in neurological diseases.
- Clinical Research: A subset of angiotensin IV (AngIV)–related molecules is known to possess procognitive/antidementia properties and has been considered as templates for potential therapeutics. However, this potential has not been realized because of two factors: A lack of blood-brain barrier–penetrant analogs and the absence of a validated mechanism of action.
The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, blood-brain barrier–permeable analog N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide (dihexa). Therefore, the goal of this study was to elucidate the mechanism that underlies dihexa’s procognitive activity. Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering.
Furthermore, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis, similar to HGF. These actions were inhibited by an HGF antagonist and a short hairpin RNA targeting c-Met. Most importantly, the procognitive/antidementia capacity of orally delivered dihexa was blocked by an intracerebroventricularly delivered HGF antagonist, as measured using the Morris water maze task of spatial learning.
Benoist, Caroline C et al. “The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.” The Journal of Pharmacology and Experimental Therapeutics vol. 351,2 (2014): 390-402.
DSIP
DSIP is a well-known neuromodulator and natural somatogenic nonapeptide with many other physiological functions. It is typically found in the brain and easily passes the blood-brain barrier. It is mainly prescribed for the treatment of pain conditions, alcohol and opioid withdrawal, CRH and stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti-oncogenic protein. It has been discovered and studied for over 40 years, yet its mechanism of action remains complex and poorly understood. Studies of DSIP and its analogs over the past 30 years, since its discovery, indicate that DSIP is a unique member of the peptide neuromodulator family. It exhibits a pronounced stress-protective effect and reduces stress-induced metabolic and functional disorders in humans and animals exposed to various stressors. Some effects of the peptide are achieved through systemic antioxidant action and modulation of GABAergic, glutamatergic, and other neuronal systems. It also examines the expression of early-response genes in brain regions and the activity of biosynthetic and proteolytic processes. DSIP has traditionally been dosed as an IV infusion. However, it can also be given subcutaneously. Traditional doses have been 100mcg.
- Clinical Research: Is DSIP More Than a Sleep Peptide?
In several species, low doses of DSIP have been shown to promote sleep. Although its physiological role remains unclear, DSIP illustrates several concepts applicable to other brain peptides. These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form.
Concepts applicable to one neuropeptide appear to be applicable to others. In this article, Abba Kastin and colleagues review the known effects of DSIP and argue that further work is needed before it can be considered functional.
Epitalon (Anti-Aging)
Epitalon is known for its powerful life-extending and anti-aging properties, increasing telomerase production to strengthen and lengthen telomeres. Benefits of Epitalon therapy include increased lifespan, improved energy, more restful sleep, and disease prevention.
- Benefits: Supports Healthy Aging & Longevity
Epitalon helps slow down the aging process and extends longevity by increasing the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This decreases cell death and degeneration, extends cell lifespan, and prevents age-related diseases.
- Helps Reduce Stress: Epitalon helps reduce emotional stress and acts as a powerful antioxidant, eliminating oxygen-free radicals that damage and kill cells.
- Helps Reduce Stress: By stimulating telomerase production and the pineal gland, Epitalon helps inhibit tumor growth and prevent a wide range of age-related diseases, including heart disease and dementia, by eliminating free radicals.
- About Epitalon: Epitalon, also known as Epithalon, is the synthetic version of the polypeptide Epithalamin, which is naturally produced in the pineal gland in the brain. It regulates brain metabolism, increases the hypothalamus’s sensitivity to its natural hormonal influences, normalizes anterior pituitary function, and regulates gonadotropin and melatonin levels. It also helps slow the aging process by stimulating the pineal gland to producethe natural antioxidant melatonin.
- Instructions: This product is lyophilized (freeze-dried) and must be reconstituted (mixed) prior to injection. Once reconstituted, it must be stored in the refrigerator. Instructions and mixing materials are included with each kit.
Semaglutide (Weight Loss)
Semaglutide is a GLP-1 receptor agonist, meaning that it mimics the action of the human incretin glucagon-like peptide-1 (GLP-1), thereby increasing insulin secretion, increasing blood sugar disposal, and improving glycemic control. AOD stands for anti-obesity drug. AOD-9604 was originally developed to be used as an anti-obesity drug and is known to help burn fat and support weight loss. AOD-9604 is a modified fragment of human growth hormone (HGH). AOD-9604 injection therapy can be prescribed to help stimulate the pituitary gland (similarly to HGH and other growth hormones), to boost metabolism, and support weight loss.
- Benefits: Supports Weight Loss
AOD-9604 injection therapy helps regulate fat metabolism by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the conversion of dietary carbohydrates into body fat). As a result, greater weight loss is achieved over time, as more calories are burned than with standard dietary restrictions or exercise alone.
AOD-9604 triggers fat release from obese fat cells more predominantly than lean ones. It mimics the way natural growth hormone regulates fat metabolism with no adverse effects on blood sugar or tissue growth. Studies have shown that OD-9604 is highly effective as a fat burner.
- About AOD-9604: AOD-9604 is a peptide fragment of human GH. Studies suggest that AOD-9604 stimulates lipolytic (fat-burning) and anti-lipogenic (anti-fat-producing) activity. AOD-9604 does not increase GH levels. It works by mimicking the way natural growth hormone regulates fat metabolism. AOD-9604 injection therapy is ideal for individuals seeking fat loss because it doesn’t increase hunger or raise cortisol levels, unlike other peptide products such as GHRP (GHRP-6, GHRP-2, or GHRH) or synthetic GH.
Studies have shown that, in addition to its fat-loss properties, AOD-9604 exhibits regenerative properties associated with GH, and clinical trials are underway to evaluate its use in osteoarthritis, hypercholesterolemia, and bone and cartilage repair.
AOD 9604 has an excellent safety profile and recently obtained Human GRAS status in the USA.
Instructions: Once reconstituted, it must be stored in the refrigerator. Instructions and mixing materials are included with each kit.
